DNASE1 and neoplasm: We chose FITC (fluorescein isothiocyanate)‐labeled bovine serum albumin and enhanced green fluorescent protein as the protein cargos to visualize their cytosolic access, β‐galactosidase to verify the protein bioactivity and cellular uptake mechanism, and deoxyribonuclease I (DNase I) to test its anti‐tumor efficacy.