PSA, polysaccharide A; DMARD, disease-modifying antirheumatic drug; SL, sphingolipid; CID, chronic inflammatory disease; SpA, spondyloarthritis; PUFA, polyunsaturated fatty acid; MD, Mediterranean diet; MTX, methotrexate; MAPK, mitogen-activated protein kinase; JAK, Janus kinase. The gene discussed is WNK2; the disease is spondyloarthropathy.