Since it has been suggested that primary afferent neurons convey nociceptive signaling to second order neurons and glial cells located mainly in the SDH and NP regions of the spinal cord dorsal horn (Todd, 2010), progesterone- and P450c17-induced modulation of astrocytes in these regions could certainly affect spinal nociceptive signal transmission following peripheral nerve injury. Here, CYP17A1 is linked to peripheral nerve injury.