Whether the activity of P450c17 changes in astrocytes of the lumbar spinal cord in accordance with pain remains to be determined, but it is interesting to speculate that an increase in astrocyte P450c17 activity could alter the effect of progesterone treatment on pain, as well as, on the pathophysiological changes that occur in astrocytes following peripheral neuropathy. Here, CYP17A1 is linked to peripheral neuropathy.