CASP3 and hepatocellular carcinoma: As shown in Figure 5G, both Ki-67 and PCNA were significantly decreased in iberverin-treated Huh7.5.1 xenograft tumors, whereas cleaved Caspase-3 was remarkably increased, suggesting that iberverin could inhibit tumor growth of HCC by suppressing cell proliferation and promoting cell apoptosis in vivo.