First, we determined whether Notch, IL-1, and leptin signaling could be involved in the regulation of NOTCH1, JAGGED1, LEPTIN, ObRb, IL-1β, IL-1R, VEGF-A, VEGFR1, and VEGFR2 gene expression in colorectal tumor tissues. This evidence concerns the gene IL1R1 and colorectal neoplasm.