We detected a significant increase in mRNA levels of Interleukin (IL)-1β, IL-17 and the chemokines Cxcl1 and Cxcl2 which are important neutrophil chemoattractants (corresponding to Cxcl8 in humans) in gingival tissue derived from CD73-deficient animals with periodontitis when compared to the WT (Figures 1A,B,F,G). This evidence concerns the gene NT5E and periodontitis.