Previous studies have shown that patients with anti-CASPR2 encephalitis demonstrate a wide range of symptoms, including central nervous system symptoms, such as encephalopathy, and peripheral symptoms, such as peripheral nerve hyperexcitability/neuromyotonia (myokymia, fasciculations, cramps) and neuropathic pain (15, 16). This evidence concerns the gene CNTNAP2 and Encephalopathy.