In the cardiac dysfunction of patients with Alzheimer’s disease and mice with APP1/PS1 mutations, APP1/PS1 mutations impair mitochondrial integrity leading to leakage and accumulation of mtDNA in the cytosol, which continuous stimulates cGAS-STING signaling resulting in reduction of cGAS-STING activity, and then reduced activation of autophagy and mitophagy via cGAS-STING signaling and further accumulation of damaged mitochondria and beta-amyloid in the cardiomyocytes, eventually initiating cardiac dysfunction (122). This evidence concerns the gene CGAS and early-onset autosomal dominant Alzheimer disease.