It was also recently reported that TRIM18 and TRIM29, both of them are member of TRIM family proteins, function as a key negatively regulator for the innate immune response induced by viral infection (including DNA or RNA virus) through inhibiting the activation of cGAS-STING induced by accumulation of viral DNA or RNA in cytosol, and leads to the persistence of DNA or RNA viruses, however, knockdown or knockout of them separately enhances type I interferon production through activating of cGAS-STING induced by virus DNA or RNA, and subsequent to clear viruses. The gene discussed is STING1; the disease is viral infectious disease.