In dilated hypertrophic hearts, such as diabetic cardiomyopathy and MI, the production of ROS induced by stress leads to mitochondrial damage, which triggers the release of mtDNA into the cytosol, activates cGAS-STING signaling, and results in the phosphorylation of IRF3 and NF-κB by the kinase TBK1 and IKKs respectively. This evidence concerns the gene IRF3 and myocardial infarction.