For virus, DNA virus infection will cause its DNA fragments to be recognized by cGAS, which promotes activation of the cGAS-STING signaling, while RNA virus infection can also trigger cGAS-STING mediated innate immunity, but the effectors is mtDNA or chromosomal DNA in the cytosol induced by virus infection rather than RNA of virus origin (138). This evidence concerns the gene STING1 and viral infectious disease.