FCGR2A and neoplasm: However, we demonstrated that even if the YTE IgG1 mutation reduced FcγR binding and ADCC, the partial Fc-effector function of KVA12123 mAb was preserved, resulting in its potent single-agent anti-tumor efficacy in cold tumor models compared to an IgG4 or an Fc-Null IgG which possess poor or no effector functions (Figure 6).