CD40LG and skin disorder: In particular, the IgM fraction of auto-reactive antibodies against ACHRG in pneumonitis, cytokeratin 19 in dermatitis, and IgG antibody against thyroglobulin during hepatitis were elevated during the time of toxicity compared with 12-week control samples and showed an increase from baseline to the time of toxicity among pneumonitis, dermatitis, and hepatitis cases, respectively, and should be investigated further.