In particular, the IgM fraction of auto-reactive antibodies against ACHRG in pneumonitis, cytokeratin 19 in dermatitis, and IgG antibody against thyroglobulin during hepatitis were elevated during the time of toxicity compared with 12-week control samples and showed an increase from baseline to the time of toxicity among pneumonitis, dermatitis, and hepatitis cases, respectively, and should be investigated further. This evidence concerns the gene CHRNG and pneumonitis.