From these 12 factors, 10 factors (i.e., TP63, SQLE, SLC7A5, SLC7A11, PTGS2, PROM2, MT3, IL33, ANO6, ALOX15B) that contributed the most to the prognosis of breast cancer patients were screened out based on an optimal value of λ (Figures 2C, D). Here, IL33 is linked to breast cancer.