SHBG and Varicose veins: Among the tested exposures, the MR estimates from the RE-IVW method indicated that higher serum SHBG levels significantly increased the risk of lower extremity varicose veins (OR=1.39; 95% CI: 1.13–1.70; P=1.58×10-3), and directions of the MR-Egger and WM methods were consistent with that of the IVW method.