SHBG and Varicose veins: Gender-stratified MR showed that genetically predicted higher serum SHBG levels were associated with lower extremity varicose veins in both females and males, and the OR of serum SHBG levels on lower extremity varicose veins risk in females (ORfemale=1.51; 95% CI: 1.23–1.87; P=1.00×10-4) was greater than in males (ORmale=1.26; 95% CI: 1.04–1.54; P=1.86×10-2).