However, the OR of serum SHBG levels on lower extremity varicose veins risk in females (OR=1.51; 95% CI: 1.23–1.87; P=1.00×10-4) was greater than in males (OR=1.26; 95% CI: 1.04–1.54; P=1.86×10-2). Here, SHBG is linked to Varicose veins.