AKR1C3 and polycystic ovary syndrome: Multiple studies have reported that TCs in patients with PCOS are predisposed to generate more androgens due to overactive and overexpressed steroidogenic enzymes, such as CYP17A1, CYP11A1, HSD3B2, SRD5A1, and 17β-HSD5 (also known as AKR1C3) (46).