We conducted an eQTL study on the 58 SNPs involved in the MR analysis, and found that rs6585827 corresponding to the PLEKHA1 gene is an eQTL variation that affects the expression of the gene, and the rs6585827 mutation from G to A suppresses the expression level of PLEKHA1 and lower risk of T2DM relevant. Here, PLEKHA1 is linked to type 2 diabetes mellitus.