Abnormally expressed lncRNA takes part in the invasion and metastasis of NSCLC by regulating the expression of signaling pathway genes, such as phosphoinositide 3-kinase (PI3K) (Jiang W. et al., 2020), mitogen-activated protein kinase (MAPK) (Zhang et al., 2018), Wnt/β-catenin signaling (Liu S. et al., 2020), TGF-β/SMAD signaling (Fan et al., 2023b), and Hippo (Zeng et al., 2021). The gene discussed is TGFB1; the disease is non-small cell lung carcinoma.