Tumor cells acquire resistance to therapy via several mechanisms, including transporter pumps, oncogenes (EGFR, PI3K/AKT, ERK, and NF‐κB), tumor suppressor genes, exosomes, DNA repair, autophagy, epithelial‐mesenchymal transition (EMT), cancer stemness, and mitochondrial alteration.2 The gene discussed is AKT1; the disease is cancer.