In this study, using snRNA‐seq, we identified the microglial subcluster in cerebral ischemia, characterized by significant up‐regulation of Trem2 and Igf1, enhancement of OXPHOS and microglial activation, along with characteristics such as phagocytosis and proliferation, consistent with previous studies.[12] Interestingly, this microglial subcluster exhibited neuroprotective effects on surrounding cells via secretion of various ligands including IGF1, implying that activation of this microglial subcluster could be an endogenous protective mechanism toward ischemic injury. The gene discussed is IGF1; the disease is brain ischemia.