BRD2 and neoplasm: However, in our dataset, similar to previously published studies, a reduction in tumor size does not correlate with OS (Fig. 3a) and up to 22% of PDAC patients have tumors that do not secrete CA19-9.5,6,38 Thus, novel predictive methods are needed to estimate patients’ margin status, with the goal of having novel clinical tools that can guide the utilization of alternative strategies (e.g., radiotherapy) in conjunction with NAT if positive margins are anticipated.