HNF4﻿α, downregulated by PL + CO in the duodenum, binds LA and plays a critical role in maintaining intestinal health, intestinal epithelial differentiation and barrier function65–67; it is also dysregulated in colon cancer as well as colitis and is an IBD susceptibility gene4,68,69. The gene discussed is HNF4A; the disease is colonic neoplasm.