On the other hand, several chemical agents have been investigated in SGCs, such as target therapy for vascular endothelial growth factor receptor (VEGF) and epidermal growth factor receptor (EGFR) signaling in ACC, and histone deacetylase and the mammalian target of rapamycin (mTOR) in MEC (30). Here, VEGFA is linked to adrenal cortex carcinoma.