In KC-HCF CM, RB-PDT significantly decreased EGF, HGF and TGF-β concentration (p<0.01; p = 0.03; p<0.0001) and increased FGFb concentration (p<0.01), compared to controls (Fig 6F, 6G, 6I and 6J). The gene discussed is TGFB1; the disease is keratoconus.