Indeed, an accumulating wealth of data has demonstrated that cDC1 occupy a central position in regulating various aspects of CD8 T-cell responses to viral infections: Batf3-dependent lung cDC1s are required for transport of viral antigens to the mediastinal lymph node (MLN), where they induce CD8 T-cell immunity against influenza or Sendai virus [20, 26, 27]. This evidence concerns the gene MPPE1 and viral infectious disease.