TRV027, given centrally, reduced blood pressure of mouse made hypertensive with the mineralocorticoid deoxycorticosterone acetate.33 TRV027 also reduced vessel dilation in an aortic aneurysm study in high-fat-diet-fed ApoE (apolipoprotein E gene)-null mice infused with Ang II.34 However, olmesartan produced an even more pronounced effect on vessel cross-sectional area and elastin content. The gene discussed is APOE; the disease is aortic aneurysm.