NR3C2 and hydrops fetalis: When patients with AHF can tolerate higher doses of GDMT, results suggest that all efforts should be made to rapidly uptitrate to optimal doses of the 3 and (likely) 4 pillars of HF medications, including renin-angiotensin receptor system inhibitors, β-blockers, mineralocorticoid receptor antagonists, and sodium-glucose transport protein 2 inhibitors.