Interestingly, mutations in MANBA are known to affect kidney function [52], blood pressure [53] and cardiovascular disease [54], while the monogalactosylated IgG glycan (G1) (that MANBA affects in our in vitro expression system) was previously identified as the best predictor of future cardio vascular events in women [55, 56]. The gene discussed is MANBA; the disease is cardiovascular disorder.