This process is defective in insulin resistance, a significant risk factor for cardiometabolic diseases such as type 2 diabetes (James et al., 2021), heart failure (Riehle and Abel, 2016), and some types of cancer (Leitner et al., 2022), and so defective GLUT4 translocation represents one of the hallmarks of insulin resistance. The gene discussed is SLC2A4; the disease is Insulin resistance.