Multivariate logistic regression analyses revealed that weight (OR = 0.91, 95%CI = 0.85–0.96), height (OR = 3.54, 95%CI = 1.60–7.81), BMI (OR = 0.61, 95%CI = 0.46–0.80), systolic BP (OR = 0.98, 95%CI = 0.96–1.0), smoking (OR = 5.46, 95%CI = 1.62–18.35), diastolic BP (OR = 0.95, 95%CI = 0.90–0.99), sex (OR = 0.22, 95%CI = 0.06–0.71) and the expression levels of ANRIL (OR = 2.05, 95%CI = 1.74–2.35) and circANRIL (OR = 13.63, 95%CI = 3.74–49.60) in PBMCs were potential transcriptional biomarkers for CAD. Here, CDKN2B-AS1 is linked to coronary artery disorder.