This possibility is supported by immunoglobulin genes being significantly more highly expressed in the Lyn-high/PCA group 3/4 tumours (Table S9), the enrichment of this tumour group for ‘inflammation and immunity’-associated genes (Fig. 6) and the known high expression of Lyn in immune cell subsets, particularly in B cells (Brian and Freedman, 2021). Here, LYN is linked to neoplasm.