5-LO-derived products are of relevance for various inflammatoryand allergic disorders, with one small-molecule 5-LO inhibitor—zileuton—beingapproved against asthma.17 5-LO also playsan important role in acute myeloid leukemia, as recently disclosedby us.18,19 Thus, it is conceivable that some naturalproducts with anti-inflammatory properties could modulate the activityof this pathway. This evidence concerns the gene ALOX5 and acute myeloid leukemia.