PLPP3 and Stroke: Recent studies have shown that circSCMH1 can increase the ubiquitination-modified fat mass and obesity-associated protein (FTO) translocation to endothelial cell nucleus, leading to the N6-methyladenosine (m6A) demethylation of phospholipid phosphatase 3 (Plpp3) mRNA, thereby enhancing its expression and promoting vascular repair after stroke (19).