demonstrated that exercise optimised local immunity when combined with anti-PD1 by raising CD3 T cell and cytotoxic CD8+ T cell infiltrations and subsequently led to significant tumour size reduction compared to anti PD-1 alone in their PDA murine model (orthotopic transfer of KPC cells to wild type C57BL/6 mice) (27). Here, PDCD1 is linked to Patent ductus arteriosus.