However, the activities of manganese superoxide dismutase (MnSOD) and CAT are significantly decreased in Tregs of mice with experimental autoimmune encephalomyelitis (EAE), which impairs the ability of the antioxidant system to scavenge mtROS and results in mtROS accumulation (Figure 1) (31). Here, SOD2 is linked to experimental autoimmune encephalomyelitis.