Necroptosis mediated by RIPK3 promoted the accumulation of immunosuppressive myeloid-derived suppressor cells (MDSCs) in tumor microenvironment (TME) of pancreatic cancer through producing C-x-c motif chemokine ligand 1 (CXCL1) and CXCL5 (18, 19). Here, CXCL1 is linked to neoplasm.