The novel mast cells were predicted to interact with CD8+ T cells via IL10 signaling pathway, and highly expressed AVP and CTSG. Consistently, AVP (57) and CTSG (58) have been reported to play important roles in inflammation and immune response, and IL10 has been shown to potentiate IFN-γ and induct the cytotoxicity of CD8+ T cells (68, 81–83), thereby triggering anti-tumor immune responses. This evidence concerns the gene CD8A and neoplasm.