Our results are consistent with Rehman et al.’s observations (Rehman et al., 2020) indicating that SLC26A4 is a key player in CF ASL alkalinization and the recent publication of Guidone et al. showing that YS-01 significantly decreased ASL pH in both CF and non-CF epithelia treated with IL-17/TNF-α (Guidone et al., 2022). The gene discussed is TNF; the disease is cystic fibrosis.