CXCL8 and Decreased total neutrophil count: As in humans, our model showed neutropenia and elevated IL-8 (CXCL-8) levels (Thommasen et al., 1984), which resulted in massive neutrophil recruitment into the lungs as shown through longitudinal histopathological analysis and consistent with the exudative phase of clinical acute respiratory distress syndrome (Antcliffe et al., 2018).