AKT1 and rheumatoid arthritis: As shown in Figure 4B and Table 3, the KEGG enrichment analysis revealed that it primarily affected the IL-17 signaling pathway and the NOD-like receptor pathway in the biological system, rheumatoid arthritis, atherosclerosis, and cancer in disease, and affected cytokine and receptor interactions and the PI3K-AKT, JAK-STAT, MAPK, and Rap1 pathways in the signal pathway.