The present study confirms the results recently proposed by Alexeeva et al. (21) regarding the effective role of CAN in 46 patients with sJIA previously administered the IL-6 inhibitor tocilizumab, extending the concept to the whole spectrum of Still’s disease (both sJIA and AOSD) and confirming the results, regardless of the biologic agents previously used. This evidence concerns the gene IL6 and systemic-onset juvenile idiopathic arthritis.