MS-275 reduced the activity of HDAC3 and downregulated the expression of the chromatin remodeling enzyme SMARCA4, which in turn reduced the activity of miR-27a, leading to decreased expression of PAX3:FoxO1, and destabilization of mRNA in ARMS cells (Bharathy et al., 2018). Here, FOXO1 is linked to alveolar rhabdomyosarcoma.