The cytochrome c release was affected by the main effect of diabetes (F (1, 8) = 110.1, P < 0.0001) and exercise (F (1, 8) = 11.78, P = 0.009), as well as the interaction effect of diabetes by exercise (F (1, 8) = 6.3, P = 0.04). Here, CYCS is linked to diabetes mellitus.