Conversely, compared to control, randomization to low-dose aerobic exercise statistically significantly reduced hs-CRP: −35.4% (95% CI: −70.1, −0.7) and IL6: −29.6% (95% CI: −58.4, −0.8), but not sTNFαR2: 2.7% (95% CI: −15.7, 21.1) in subjects with stage III cancer, whereas randomization to high-dose aerobic exercise was not associated with a reduction in any inflammation outcome in subjects with stage III colon cancer. The gene discussed is IL6; the disease is malignant colon neoplasm.