KMT2A and non-small cell lung carcinoma: Recruitment of the histone H3 lysine 4 methyltransferase MLL has been suggested to occur through the binding to the lncRNA MIAT, which can then guide MLL to the promoter region of the collagen degradation enzyme MMP9. Inhibition of MIAT resulted in the loss of transcriptional activity of MMP9, which is suggested to reduce proliferative capacity and cell migration in non-small cell lung cancer (68).