Research suggests that in prostate cancer, the elevation of circCSPP1, potentially catalyzed by HnRNP-L, triggers cellular autophagy via the circCSPP1-miR-520h-EGR1 axis, therefore, the HnRNP-L-regulated circCSPP1/miR-520h/EGR1 axis plays a pivotal role in modulating autophagy and advancing prostate cancer (129). This evidence concerns the gene EGR1 and Familial prostate cancer.