In conclusion, akin to METTL3, METTL4, METTL16, WTAP, RBM15/15B, VIRMA, and ZC3H13, the potential influence of YTHDC1, YTHDC2, YTHDF, IGF2BPs, the HNRNP family, eIF3, FTO, and ALKBH3/5 on autophagy is intertwined with their roles in RNA metabolism, collectively regulating autophagy in cancer (Table 1). The gene discussed is FTO; the disease is cancer.