SEMA4C and allergic disease: Considering the indispensable contribution of semaphorins and their receptors in allergic diseases, this study was conducted to compare the efficacy of combined budesonide and fexofenadine versus combined fluticasone propionate and fexofenadine on the gene expression of SEMA4A, SEMA4C, SEMA4D, Plexin-B2, and Plexin-D1 as well as evaluation of IgE levels and the percentages of eosinophil in the peripheral blood cells of patients with AR.