Regarding astrocytes, we found higher GFAP/S‐100 surface staining intensities in both AD‐tau and AD‐tau/Aβ, with a more robust effect size in animals co‐injected with Aβ (Figure 5B; Mann‐Whitney test: “pooled CTL” vs. AD‐tau/sham, p = 0.055; “pooled CTL” vs. AD‐tau/Aβ p = 0.008). Here, MAPT is linked to Alzheimer disease.