MAPT and Alzheimer disease: In AD‐tau/sham and AD‐tau/Aβ macaques, tau pathology spread from the entorhinal to the hippocampal trisynaptic loop and the cingulate cortex, resuming the experimental progression of Braak stage I to stage IV in 18 months (as in humans, the macaque anterior cingulate has direct connections with the entorhinal cortex and the hippocampus53).