In the current study, we detected CD5 expression in one (4%) of WR‐DLBCL, and this case did not have a relapse after achieving CR, whereas two (4%) of 43 cases of LN‐DLBCL were positive for CD5, and the 5‐year OS for these two cases was 50%. Here, CD5 is linked to diffuse large B-cell lymphoma.