FAS is a prototypical apoptosis‐inducing death receptor in the tumor necrosis factor receptor (TNFR) superfamily.[9] Once binding to FAS ligand (FASL) or accumulating on membrane, FAS trimerizes automatically and sequentially activates various intermediary proteins including FADD, caspase8 and caspase3, leading to apoptosis eventually.[10] As a result, the FAS‐dependent apoptosis of cancer cells triggered by activated CD8+ T cell is considered as an important immunosurveillance of host malignancy. The gene discussed is CD8A; the disease is cancer.