As reported, T cells, especially cytotoxic T lymphocytes immune infiltration of human colorectal cancer is associated with favorable clinical outcome.[23] To understand the immune infiltration in colorectal cancer based on PIR and FAS expression, we used TCGA‐COAD data to compare the transcriptional profile of the immune cell subpopulations in human colorectal cancer. The gene discussed is PIR; the disease is colorectal cancer.