TNF and neoplasm: Meanwhile, the effector cytokines tumor necrosis factor (TNF)‐α, interferon (IFN)‐γ, and interleukin (IL)‐2, secreted by both original CAR‐T cells and CAR‐ap‐enriched CAR‐T cells, could be significantly elevated when co‐incubated with tumor cells (Figure 3c).