We suggest that the increased appearance of small, category 4 shapes in WT mouse LECs upon tumor challenge was at least in part because of VEGFA up-regulation in the hypoxic tumor environment and signal transduction via VEGFR2 pY949 and c-Src (Weis et al, 2004; Li et al, 2016), causing VE-cadherin internalization and degradation. Here, CDH5 is linked to neoplasm.