The three major genes implicated in genetic FTLD are microtubule-associated protein tau (MAPT), progranulin (GRN) and chromosome 9 open reading frame 72 (C9orf72), where MAPT mutations are associated with a primary tauopathy and GRN and C9orf72 are associated with TDP-43 pathology (Panza et al., 2020). This evidence concerns the gene C9orf72 and tauopathy.