Also in large mammalian dogs UTMD -mediated Ang 1 gene transfection could be observed from day 1 to 1 month after MI, the UTMD-Ang1 group showed a significant reduction in plasma norepinephrine and N-terminal pre-B-adrenergic peptide (NT-proBNP) from day 1 to 1 month after MI, exhibiting significant effects of promoting angiogenesis and reversing LV structure and sympathetic remodeling (Cao et al., 2021). This evidence concerns the gene ANGPT1 and myocardial infarction.